Without greater vaccination, living with COVID could mean enduring a yearly death toll that is an order of magnitude higher than the one from flu. And yet this, too, might come to feel like its own sort of ending. Endemic tobacco use causes hundreds of thousands of casualties, year after year after year, while fierce public-health efforts to reduce its toll continue in the background. Yet tobacco doesn’t really feel like a catastrophe for the average person. Noymer, of UC Irvine, said that the effects of endemic COVID, even in the context of persistent gaps in vaccination, would hardly be noticeable. Losing a year or two from average life expectancy only bumps us back to where we were in … 2000.